Giorgio Giuseppini has subsequently started a brilliant career, having performed in the major opera and concert houses throughout Europe. His past seasons were marked by several successful interpretations of the main Verdi's operas, such as Aida (performed in Caracalla and at the Théâtre du Capitole de Toulouse), Rigoletto (at the Teatro Carlo Felice di Genova), Il trovatore (at the Teatro dell'Opera di Roma, at the Maggio Musicale Fiorentino), Nabucco (at the Teatro Carlo Felice di Genova and at the Sferisterio di Macerata), Simon Boccanegra, Jérusalem and La forza del destino at the Teatro Regio di Torino, I masnadieri, Macbeth at Royal Opera House Muscat, Don Carlo at the Teatro Massimo di Palermo.
Giorgio Giuseppini also performed in Donizetti's Lucia di Lammermoor at the Macerata Opera Festival, in Bellini's Norma (at the Zürich Opernhaus and Gran Teatre de Liceu in Barcelona) and in Puccini's Turandot (at the Royal Opera House, Covent Garden in London, at the Arena di Verona and at the Teatro Comunale di Bologna), as well as in Benvenuto Cellini and Maria Stuarda at the Opera di Roma, Caterina Cornaro at Teatro Donizetti di Bergamo, Don Giovanni in Santiago, Chile, La Gioconda in Genoa, Werther at the Teatro Comunale di Bologna (recorded for Decca). He has been recently heard in Don Carlo at the Nederlandse Opera, Amsterdam, La Sonnambula (Conte Rodolfo) in Zürich and Médée at Théâtre du Châtelet.
Giorgio Giuseppini also enjoys a successful collaboration with the Teatro alla Scala, where he appeared in such numerous works as Don Carlo, Les Troyens, Rigoletto, Il trovatore, Lucia di Lammermoor, Sigismondo, Rossini's Petite messe solennelle, I due Foscari, Moïse et Pharaon, La Gioconda and Nabucco.
During his career Giorgio Giuseppini has performed under the baton of some of the most outstanding conductors, such as Zubin Mehta, Riccardo Muti, Colin Davis, Daniele Gatti, Gianandrea Gavazzeni, Riccardo Chailly, Roberto Abbado and Raphael Frühbeck de Burgos.
In the next future he will perform La Gioconda in Beijing, Rigoletto at Opera di Firenze under the baton of M. Zubin Mehta and Il barbiere di Siviglia and Les pêcheurs de perles for the opening night of the New Dubai Opera Theatre.